Pharmaceuticals from
Tomatoes – How to Turn Plants into Bio–Factories
Every child knows that
fruits and vegetables are healthy - but are they also healthy for the process
industry? Scientist have found a way of using fruity tomatoes as small–scale
bio–factories for pharmaceuticals.
Fruits and vegetables
are healthy. This is something every child knows. However, we would need to
consume high amounts of many plant products to achieve an efficient dose of
helpful natural compounds, because those are often low-concentrated in plants.
Scientists of Dr.
Alisdair Fernie’s research group at the Max Planck Institute of Molecular Plant
Physiology (MPI-MP) and of Prof. Cathie Martin’s group from the John Innes
Center, England, described a possibility to use crop plants for large scale
production of natural compounds. They published their findings in the journal
“Nature Communications”.
Medically relevant
substances in plants are so called secondary metabolites, including e.g.
pigments and deterrents that enable plants to protect themselves against pests.
They are not only useful for the plant itself, but can be helpful for humans as
well. The beneficial effects of most medicinal plants are a consequence of them
containing these substrates.
Making the Valueable
Ingredients Available
Two medical compounds,
namely resveratrol and genistein, belong to the phenylpropanoides. Resveratrol
is found in grapes naturally and it has been reported to extend the lifespan of
different animals. Genistein, a secondary product in soybean, has been
suggested to play a role in the prevention of different cancers, particularly
breast cancer.
However, nobody has the
ability to drink 50 bottles of wine or to eat 2.5kg soybeans per day – this
would be the necessary amount of consumption to receive the beneficial dose of
these natural products. The researchers in Germany and England sought for
another way to make these compounds available.
The Biological
Production Switch
For this purpose, the
scientists analyzed a gene which is responsible for the production of the so
called AtMYB12 protein. This protein itself can actively regulate the
phenylpropanoid production. The researchers used the model plant Arabidopsis
thaliana for their experiments, a herb which is growing all over the world.
“This protein is working
like a switch, which can turn the production of secondary plant substances on
or off”, describes Alisdair Fernie, research group leader at the MPI MP in
Potsdam.
http://www.process-worldwide.com/plant-projects-and-engineering/articles/510330/?cmp=nl-206
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